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1. Examiners Reports
2. Primary exam requirements

2.2.1 General anaesthesia and sedation

Pharmacodynamics

1. Drug Actions
2. Receptor Activity
3. Dose-Effect Relationships
4. Efficacy and Potency
5. Mass Action, Affinity and Dissociation
6. Mechanisms of Adverse Drug Effects

Pharmacokinetics

1. The Compartment Model and Definitions
2. Absorption
3. Factors Influencing Drug Distribution
4. Drug Clearance Mechanisms
5. Drug Metabolism
6. IV and Infusion Kinetics
7. Drug Monitoring

2.2.3 Regional and local anaesthesia

1. The Physiology of Nerve Conduction
2. Physiological Consequences of Central Neuraxial Blocks
3. Pharmacology of Local Anaesthetics
4. Anatomy of the Vertebral Column, Spinal Cord and Meninges
5. Describe the Dermatomal Innervation
6. Describe the Myotomal Innervation
7. Describe the Pain and Sensory Pathways
8. Principles of Ultrasound Imaging and the Safe Use of Ultrasound Equipment for Regional Anaesthesia
9. Principles of Nerve Stimulation to Locate Nerves and the Safe Use of Nerve Stimulators

2.2.4 Perioperative medicine

Respiratory anatomy and physiology

Model Answers

1. Chest Wall & Diaphragm
2. Lower Airway Anatomy
3. Anatomy of Pulmonary and Bronchial Circulation
4. Control of Ventilation and Alteration in Anaesthesia
5. Nature and Function of Surfactant
6. Lung Compliance and Elastic Properties
7. Fast and Slow Alveoli, and Time Constants
8. Chest Wall and Pressure/Volume Relationships of Lung/Chest Wall
9. Vertical Pleural Pressure Gradient and its Significance
10. Gas Flow and Resistance Physics in the Lung
11. Airway Resistance and its Measurement
12. Closing Capacity
13. Work of Breathing
14. Altered Lung Mechanics in Disease
15. Lung Volumes/Capacities and their Measurement
16. Dead Space and Bohr/Alveolar Gas Equations
17. Composition of Ideal Alveolar/Mixed Expired Gas
18. Oxygen Cascade
19. Alveolar Exchange of CO2 and O2
20. Diffusion Capacity
21. Normal VQ Matching
22. West Lung Zones
23. Shunt Equation
24. VQ Mismatch and Venous Admixture
25. Oxygen Carriage and Storage
26. CO2 Carriage and Storage
27. Pulmonary and Systemic Circulation Differences
28. Pulmonary Vascular Tone and Resistance
29. Physiological Consequences of IPPV and PEEP
30. Physiological Effects of O2, CO2 derangement and CO
31. Discussion of Factors Affecting Ventilation
32. Define Humidity and Importance of Humidification
33. Non-Ventilation Lung Functions

Respiratory Pharmacology

1. Pharmacology of Anti-Asthma Drugs
2. Pharmacology of Drugs used in Pulmonary Hypertension
3. Oxygen Therapy

Renal Fluid and Electrolytes

1. Functional Anatomy of Kidneys and Urinary Tract
2. Physiology of Renal Blood Flow
3. Glomerular Filtration and Tubular Function
4. Counter-Current Mechanisms in the Kidney
5. Mechanisms of Renal Function Regulation
6. Endocrine Functions of the Kidney
7. The Kidney in Glucose, Nitrogenous Waste Products and Drugs
8. Measuring Glomerular Filtration Rate and Renal Blood Flow
9. Physiological Effects and Clinical Assessment of Renal Dysfunction
10. Renal Response to Hypovolaemia
11. Effects of Anaesthesia on Renal Function
12. Function, Distribution and Physiological Importance of Sodium, Potassium, Magnesium, Calcium and Phosphate Ions
13. Mechanisms Involved in Maintenance of Fluid and Electrolyte Balance
14. Constituents and Functions of Plasma
15. Regulation of Osmolality
16. Significance of Oncotic Pressure, Colloid Osmotic Pressure and Reflection Coefficients
17. Regulation of Acid/Base Balance
18. Acid-Base Chemistry Using the Henderson-Hasselbach equation and Strong Ion Difference

2.2.5 Pain medicine

Neurobiology

1. Pain/Sensory Pathway Anatomy
2. Autonomic Nervous System Anatomy
3. Physiological Mechanisms of Pain
4. Progression from Acute to Chronic Pain
5. Injury Response to Acute Pain
6. Applied Pathology/Psychology of Neuropathic Pain
7. Effects of Pain/Analgesia on Injury-Induced Organ Dysfunction
8. Pain Physiology/Peception in the Older Patient